The effect of analogue Pd(II)-, Pt(II)-, and Au(III) compounds featuring\n2-(2â??-pyridyl)benzimidazole on the aggregation propensity of amyloid-like peptides derived from\nABeta and from the C-terminal domain of nucleophosmin 1 was investigated. Kinetic profiles of\naggregation were evaluated using thioflavin binding assays, whereas the interactions of the\ncompounds with the peptides were studied by UV-Vis absorption spectroscopy and electrospray\nionization mass spectrometry. The results indicate that the compounds modulate the aggregation\nof the investigated peptides using different mechanisms, suggesting that the reactivity of the metal\ncenter and the physicochemical properties of the metals (rather than those of the ligands and the\ngeometry of the metal compounds) play a crucial role in determining the anti-aggregation\nproperties.
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